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Article

Investigating the role of double mutations R12C/P20R, and R12C/R69C on structure, chaperone-like activity, and amyloidogenic properties of human αB-crystallin.

International journal of biological macromolecules - 1 Jul 2023

Khaleghinejad Seyed Hossein, Shahsavani Mohammad Bagher, Ghahramani Maryam, Yousefi Reza

Abstract excerpt

α-crystallin is a structurally essential small heat shock protein (sHSP) with a chaperone-like activity which maintains transparency of the lenticular tissues during a period of time that is as long as human life. α-crystallin is a multimeric protein consisting of αA and αB subunits, with 57 % homology. The CRYAB gene on chromosome 11 encodes human αB-crystallin (αB-Cry), which contains 175 amino acid residues....

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PMID: 37116845
DOI: 10.1016/j.ijbiomac.2023.124590

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