Article

Metabolism-weighted brain connectome reveals synaptic integration and vulnerability to neurodegeneration

2025-10-02

Abstract excerpt

<h4>ABSTRACT</h4> The brain’s capacity for integration arises from both its structural wiring and energetically demanding electrochemical signaling. Yet current connectome analyses treat network nodes as functionally homogeneous, ignoring that neural communication is constrained by metabolic cost. Here we introduce a metabolism-weighted connectome, a fully weighted brain graph in which both connections and the me...

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Literature Corpus work: a4506b56-c6ee-526e-bb00-cbc4df02503d
DOI: 10.1101/2025.10.02.679973

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