Article

GSDMD-dependent neutrophil extracellular traps formation contributes to fibroblast-like synoviocyte activation in rheumatoid arthritis

2021-04-13

Abstract excerpt

<h4>Objective: </h4> The activation of NLRP3 inflammasome is critical for rheumatoid arthritis (RA), however, the role of gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3/ASC/Caspase-1, in RA has not been well defined. Methods Genetically susceptible mice (DBA/1J) are immunized with a type II bovine collagen emulsion in complete Freund's adjuvant (CFA). Peripheral blood neutrophi...

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Literature Corpus work: ddaa2fb3-2744-5f4a-ab86-f736a3325751
DOI: 10.21203/rs.3.rs-401936/v1

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