Article

Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

2022-07-05

Abstract excerpt

Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that complement component 5a (C5a), through its cellular receptor C5aR1, has potent proinflammatory actions, and plays immunopathological roles in inflammatory diseases, we investigated whether C5a/C5aR1 pathway could be involved in COVID-19 pathop...

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Literature Corpus work: 7c4e5603-ec0f-5d25-8686-69e687c45e08
DOI: 10.1101/2022.07.03.498624

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