Article

Gasdermin-D activation by SARS-CoV-2 trigger NET and mediate COVID-19 immunopathology

2022-01-25

Abstract excerpt

The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases of COVID-19. However, the molecular mechanisms underlying the release of NETs in COVID-19 remain unclear. Using a single-cell transcriptome analysis we observed that the expression of GSDMD and inflammasome-related genes were increased in neutrophils from COVID-19 patients. Fur...

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Literature Corpus work: d93ff6d6-9699-5cfd-9098-5ac9b6791266
DOI: 10.1101/2022.01.24.22269768

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