Article

Potential Involvement Mechanism of the S100A8/S100A9-NETs Axis in Rheumatic Heart Disease Valve Injury

2026-07-22

Abstract excerpt

<title>Abstract</title> <p>Rheumatic heart disease (RHD), triggered by Group A β-hemolytic Streptococcus, features valvular inflammation and fibrosis. The role of neutrophil extracellular traps (NETs) in RHD valvular injury remains unclarified. Here we established a rat RHD model and performed RNA sequencing on mitral valves to screen key NETs-related genes. RT-qPCR, Western blotting, immunohistochemistry and imm...

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Literature Corpus work: 5ad2bdeb-cc98-5e37-8952-d84663c5e248
DOI: 10.21203/rs.3.rs-10067280/v1

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