Back to search

Article

PDTC inhibits apoptosis and phenotypic transformation of co-culture of myeloma cells and renal tubular epithelial cells by reducing the secretion of light chain protein

2020-05-28

Abstract excerpt

<title>Abstract</title> <p>Background The human myeloma cell line RPMI-8226 is co-cultured with human proximal tubular epithelial cell HK-2, which is commonly used to simulate the renal environment in patients with multiple myeloma. This study aimed to investigate the effects of NFκB inhibitor PDTC on the viability, apoptosis and cell phenotype of HK-2 cells in the co-culture system of myeloma cells in renal tubu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
dda24306-dbcb-521c-918b-a91a5c9bd1f0
DOI
10.21203/rs.3.rs-31072/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PDTC inhibits apoptosis and phenotypic transformation of co-culture of myeloma cells and renal tubular epithelial cells by reducing the secretion of light chain proteinDOI 10.21203/rs.3.rs-31072/v1
A Rapid and Simple Procedure for the Establishment of Human Normal and Cancer Renal Primary Cell Cultures from Surgical SpecimensSemantic proximity
In Vitro to In Vivo Concordance of Toxicity Using the Human Proximal Tubule Cell Line HK-2Semantic proximity
Establishment of stable multiple myeloma cell line with overexpressed PDCD5 and its proapoptosis mechanism.Semantic proximity
Cytosolic phospholipase A2α increases proliferation and de-differentiation of human renal tubular epithelial cells.Semantic proximity
Synergistic effects of rmhTRAIL and 17-AAG on the proliferation and apoptosis of multiple myeloma cells.Semantic proximity
Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell linesSemantic proximity
HK-2 cell response to TGF-β highly depends on cell culture medium formulationsSemantic proximity
Choosing the right cell line for renal cell cancer researchSemantic proximity
Select a neighboring publication to make it the new centre.