Article
DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Dec 2017
Barton S J, Ngo S, Costello P, Garratt E, El-Heis S, Antoun E, Clarke-Harris R, Murray R, Bhatt T, Burdge G, Cooper C, Inskip H, van der Beek E M, Sheppard A, Godfrey K M, Lillycrop K A
Abstract excerpt
BACKGROUND: There is now increasing evidence that asthma and atopy originate in part in utero, with disease risk being associated with the altered epigenetic regulation of genes. OBJECTIVE AND METHODS: To determine the relationship between variations in DNA methylation at birth and the development of allergic disease, we examined the methylation status of CpG loci within the promoter regions of Th1/2 lineage...
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