Article

An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3

2022-10-08

Abstract excerpt

<h4>Structured Abstract</h4> <h4>Objective</h4> We aim to identify regulators of myosin binding protein C3 (MyBP-C) protein homeostasis. <h4>Background</h4> Variants in myosin binding protein C3 ( MYBPC3 ) account for approximately 50% of familial hypertrophic cardiomyopathy (HCM). Most pathogenic variants in MYBPC3 are truncating variants that lead to reduced total levels of MyBP-C protein. Elucidation of th...

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Literature Corpus work: dd541096-e5b5-56fc-9a39-f687c2d95f6a
DOI: 10.1101/2022.10.08.511444

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