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Article

Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models

12 Sept 2018

Abstract excerpt

Machado-Joseph disease (MJD) is a neurodegenerative disorder caused by an abnormal expansion of citosine-adenine-guanine trinucleotide repeats in the disease-causing gene. This mutation leads to an abnormal polyglutamine tract in the protein ataxin-3 (Atx3), resulting in formation of mutant Atx3 aggregates. Despite several attempts to develop a therapeutic option for MJD, currently there are no available...

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PMID: 30219871
DOI: 10.1093/hmg/ddy328

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