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Article

Monogenic lupus: it's all new!

Current opinion in immunology - 1 Dec 2017

Costa-Reis Patricia, Sullivan Kathleen E

Abstract excerpt

Monogenic lupus is rare, but its study has contributed immensely to a better understanding of the pathogenesis of systemic lupus erythematosus. The first forms identified were inherited complement deficiencies, which predisposed to lupus due to impaired tolerance, and aberrant clearance of apoptotic bodies and immune complexes. In recent years, several new monogenic disorders with a lupus-like phenotype have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29100097
DOI: 10.1016/j.coi.2017.10.008

Genes

ACP5
IFIH1
ISG15
PRKCD
RAG2
SAMHD1
TREX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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