Article

Insight into the autosomal-dominant inheritance pattern of SOD1-associated ALS from native mass spectrometry

2020-07-13

Abstract excerpt

About 20% of all familial amyotrophic lateral sclerosis (ALS) cases are associated with mutations in superoxide dismutase (SOD1), a homodimeric protein. The disease has an autosomal-dominant inheritance pattern. It is, therefore, important to determine whether wild-type and mutant SOD1 subunits self-associate randomly or preferentially. A measure for the extent of bias in subunit association is the coupling consta...

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Literature Corpus work: dd0f6ee3-c46c-5eeb-a029-3128e2adaf43
DOI: 10.1101/2020.07.13.199976

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