Article

TNF receptor associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation

2019-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the selective loss of motor neurons leading to paralysis. Mutations in the gene encoding superoxide dismutase 1 (SOD1) are the second most common cause of familial ALS, and considerable evidence suggests that these mutations result in an increase in toxicity due to protein misfolding. We previously demonstrated in the SOD1...

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Literature Corpus work: 1da7f915-935a-5b0b-ae8a-5f021b34039f
DOI: 10.1101/780460

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