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Article

Heteroaggregation of Wild-Type and ALS Mutant SOD1.

ACS chemical neuroscience - 7 Jan 2026

Dashnaw Chad M, Gonzalez Mayte, Abdolvahabi Alireza, Bassett Parker T, Lato Travis J, Balamurali Ranjana, Guberman-Pfeffer Matthew J, Shaw Bryan F

Abstract excerpt

The presence of wild-type (WT) Cu, Zn superoxide dismutase-1 (SOD1) can increase the toxicity of mutant SOD1 proteins linked to amyotrophic lateral sclerosis (ALS). The mechanism of synergy is unclear but might involve interactions between WT and mutant SOD1 in native or non-native states. One unanswered question is will the diverse rates of mutant SOD1 homofibrillization converge in the presence of WT SOD1? To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41379813
DOI: 10.1021/acschemneuro.5c00632

Genes

SOD1
NHS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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