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Article

Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease.

Human molecular genetics - 1 Sept 2009

Prudencio Mercedes, Hart P John, Borchelt David R, Andersen Peter M

Abstract excerpt

To date, 146 different mutations in superoxide dismutase 1 (SOD1) have been identified in patients with familial amyotrophic lateral sclerosis (ALS). The mean age of disease onset in patients inheriting mutations in SOD1 is 45-47 years of age. However, although the length of disease duration is highly variable, there are examples of consistent disease durations associated with specific mutations (e. g. A4V, less...

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Source

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Identifiers

PMID: 19483195
DOI: 10.1093/hmg/ddp260
PMCID: PMC2722984

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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