Article

Severe murine schistosomiasis results from disruption of the modulation of anti-egg CD4 T cell response by immunodominance of a single egg epitope

2020-05-26

Abstract excerpt

This study exploits the consistent correlation between immunodominance of the major egg antigen Sm-p40 234-246 , a robust Th1/Th17 anti-egg CD4 response and severe liver immunopathology in experimental murine schistosomiasis as an experimental platform to analyze how different degrees of immunodominance affect CD4 modulation and disease outcome. The results show that strong immunodominance of a restricted egg epi...

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Literature Corpus work: dcf4ba43-61c7-5494-b535-4d98e20f5477
DOI: 10.1101/2020.05.22.110791

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Severe murine schistosomiasis results from disruption of the modulation of anti-egg CD4 T cell response by immunodominance of a single egg epitopeDOI 10.1101/2020.05.22.110791Read

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