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Integrative reverse vaccinology approach for identification of a vaccine antigen candidate with immunoprotective and anti-fibrotic potential against <i>Schistosoma japonicum</i> -associated liver fibrosis

2025-09-06

Abstract excerpt

Schistosoma japonicum- associated liver fibrosis (SSLF) is a major cause of morbidity in Schistosomiasis, yet no licensed vaccines or specific therapies exist to prevent or treat this complication. Current vaccine development has focused mainly on infection prevention, with limited attention to pathology-driven outcomes such as fibrosis. To address this gap, we developed an in-silico pipeline integrating host sing...

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Literature Corpus work
533e5c90-3889-547b-91cf-026d78bd6815
DOI
10.1101/2025.09.02.673671
Open publication

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Integrative reverse vaccinology approach for identification of a vaccine antigen candidate with immunoprotective and anti-fibrotic potential against <i>Schistosoma japonicum</i> -associated liver fibrosisDOI 10.1101/2025.09.02.673671
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