Article

Direct specimen collection during routine operation improves nucleic acid quality in genetic analysis samples for head and neck tumors: a retrospective study

2023-08-28

Abstract excerpt

<h4>Background: </h4> The success of sequencing analysis and genetic treatment is influenced by sample quality. Preserving nucleic acid integrity in head and neck squamous cell carcinoma (HNSCC) samples is challenging owing to poor formalin fixation caused by lengthy surgical procedures and demineralization. New sampling and fixation methods are required to prevent the loss of important variants. We aimed to impro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dcdaf540-f01e-5143-ac05-c2eeaa5d05b6
DOI: 10.21203/rs.3.rs-3290506/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Direct specimen collection during routine operation improves nucleic acid quality in genetic analysis samples for head and neck tumors: a retrospective studyDOI 10.21203/rs.3.rs-3290506/v1Read

A comparison between mutational profiles in tumour tissue DNA and circulating tumour DNA in head and neck squamous cell carcinoma - A systematic review.Semantic proximity Read

Single-cell sequencing and its applications in head and neck cancerSemantic proximity Read

Use of next generation sequencing in head and neck squamous cell carcinomas: A reviewSemantic proximity Read

Next-generation sequencing (NGS) profiling of matched tumor and circulating tumor DNA (ctDNA) in head and neck squamous cell carcinoma (HNSCC).Semantic proximity Read

A straightforward assay to evaluate DNA integrity and optimize next-generation sequencing for clinical diagnosis in oncology.Semantic proximity Read

Comprehensive Genome profile testing in head and neck cancer.Semantic proximity Read

Alternative protocols of tissue fixation dramatically reduces the impact of DNA artifacts, unraveling the interpretation of clinical Comprehensive Genomic ProfilingSemantic proximity Read

The DNA integrity number and concentration are useful parameters for successful comprehensive genomic profiling test for cancer using formalin‐fixed paraffin embedded tissueSemantic proximity Read

Why Formalin-fixed, Paraffin-embedded Biospecimens Must Be Used in Genomic Medicine: An Evidence-based Review and Conclusion.Semantic proximity Read

Standardization of the preanalytical phase of DNA extraction from fixed tissue for next-generation sequencing analysesSemantic proximity Read

Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens.Semantic proximity Read

Isolation of Genomic DNA from Mammalian Cells and Fixed TissueSemantic proximity Read