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Article

A straightforward assay to evaluate DNA integrity and optimize next-generation sequencing for clinical diagnosis in oncology.

Experimental and molecular pathology - 1 Dec 2017

Bettoni Fabiana, Koyama Fernanda Christtanini, de Avelar Carpinetti Paola, Galante Pedro Alexandre Favoretto, Camargo Anamaria Aranha, Asprino Paula Fontes

Abstract excerpt

Next generation sequencing (NGS) has become an informative tool to guide cancer treatment and conduce a personalized approach in oncology. The biopsy collected for pathologic analysis is usually stored as formalin-fixed paraffin-embedded (FFPE) blocks and then availed for molecular diagnostic, resulting in DNA molecules that are invariably fragmented and chemically modified. In an attempt to improve NGS based...

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Identifiers

PMID: 29175301
DOI: 10.1016/j.yexmp.2017.11.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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