Next-generation sequencing (NGS) profiling of matched tumor and circulating tumor DNA (ctDNA) in head and neck squamous cell carcinoma (HNSCC).

doi:10.1016/j.oraloncology.2023.106358

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Next-generation sequencing (NGS) profiling of matched tumor and circulating tumor DNA (ctDNA) in head and neck squamous cell carcinoma (HNSCC).

Oral oncology - 1 Apr 2023

Economopoulou Panagiota, Spathis Aris, Kotsantis Ioannis, Maratou Eirini, Anastasiou Maria, Moutafi Myrto K, Kirkasiadou Maria, Pantazopoulos Anastasios, Giannakakou Maria, Edelstein Daniel L, Sloane Hillary, Fredebohm Johannes, Jones Frederick S, Kyriazoglou Anastasios, Gavrielatou Niki, Foukas Periklis, Panayiotides Ioannis, Psyrri Amanda

Abstract excerpt

OBJECTIVES: The aim of this pilot study was to evaluate the presence of somatic mutations in matched tumor and circulating DNA (ctDNA) samples from patients with primary head and neck squamous cell carcinoma (HNSCC) and assess the association of changes in ctDNA levels with survival. MATERIALS AND METHODS: Our study included 62 patients with stage I-IVB HNSCC treated with surgery or radical chemoradiotherapy with...

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PMID: 36871349
DOI: 10.1016/j.oraloncology.2023.106358

Genes

TP53
CDKN2A
HRAS

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