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Article

Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond.

Journal of translational medicine - 23 Apr 2025

Wen Jiaxin, Wang Yanfeng, Wang Song, Liang Yuxin, Hu Xiaozhen, Ou Qiuxiang, Bao Hua, Zhao Kuo, Wang Youyu

Abstract excerpt

BACKGROUND: Integration of immune checkpoint inhibitors (ICIs) with non-immune therapies relies on identifying combinatorial biomarkers, which are essential for patient stratification and personalized treatment. METHODS: We analyzed genomic and transcriptomic data from pretreatment tumor samples of 342 melanoma patients treated with ICIs to identify mutations and expression signatures associated with ICI response...

Read the complete abstract on PubMed

Topics

Humans
Melanoma
Immune Checkpoint Inhibitors
Mutation
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Transcription, Genetic

Middle Aged

Gene Expression Profiling

Reproducibility of Results

Aged

Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 40269853
DOI: 10.1186/s12967-025-06467-6
PMCID: PMC12020166

Genes

DNAH2
DNAH6
DNAH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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