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Article

TEAD4 Drives SKCM Progression Through COL1A2 Transcriptional Activation and Modulation of AKT/mTOR Signalling and Necroptosis-Related Phenotypes.

Experimental dermatology - 1 Jun 2026

Lin Jiaqiong, Zheng Yingchun, Shen Zongrui, Liu Qian, Liang Fangkeng, He Fei, Li Xiaoyong, Xiong Fu

Abstract excerpt

Skin cutaneous melanoma (SKCM) continues to pose significant therapeutic challenges owing to its aggressive nature and evolving resistance mechanisms. This study investigates the under-characterized role of Hippo pathway effector TEAD4 in SKCM pathogenesis through integrated multiomics analysis of clinical cohorts (TCGA, GEO, immunotherapy cohorts) combined with functional validation in A375 cell models and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42249693
DOI: 10.1111/exd.70288

Genes

TEAD4
COL1A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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