Article

Single-cell Analysis of Paired FFPE Placentas Reveals Trophoblast Reprogramming and Immune Dysregulation in Chronic Villitis of Unknown Etiology

2026-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Villitis of unknown etiology (VUE) is a common placental inflammatory lesion associated with adverse pregnancy outcomes, yet its mechanisms remain unclear. Mechanistic studies are hindered by reliance on archived formalin-fixed paraffin-embedded (FFPE) tissues, which are incompatible with standard single-cell methods. Here, we develop an FFPE-compatible single-nucleus RNA sequencing strategy and...

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Literature Corpus work: dcac5d73-6b91-5eb0-af91-7543b488daa6
DOI: 10.64898/2026.02.28.708431

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