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SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics

8 Jul 2023

Abstract excerpt

BACKGROUND: Functional placental niches are presumed to spatially separate maternal-fetal antigens and restrict the vertical transmission of pathogens. We hypothesized a high-resolution map of placental transcription could provide direct evidence for niche microenvironments with unique functions and transcription profiles. METHODS: We utilized Visium Spatial Transcriptomics paired with H&E staining to generate...

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PMID: 37423216
DOI: 10.1016/j.medj.2023.06.003

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