Article

A Multiomics, Spatiotemporal, and Single Cell Atlas for Mapping Cell-Type-Specific Dysregulation at the Maternal-Fetal Interface

2024-01-23

Abstract excerpt

The placenta, the first organ to functionally mature, undergoes disordered development in many pregnancy complications. Molecular investigations have been hampered by the extreme cellular heterogeneity of the placenta, and this complexity is further exaggerated at the maternal-fetal interface where maternal and fetal cells co-mingle. We generated the paired single nucleus epigenomes and transcriptome for each of ∼...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 040a584e-4cb9-5b3c-bcba-3edfff38baf7
DOI: 10.1101/2024.01.18.576324

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Multiomics, Spatiotemporal, and Single Cell Atlas for Mapping Cell-Type-Specific Dysregulation at the Maternal-Fetal InterfaceDOI 10.1101/2024.01.18.576324Read

Single-cell transcriptional profiling reveals cellular and molecular divergence in human maternal-fetal interfaceSemantic proximity Read

A review of single-cell transcriptomics and epigenomics studies in maternal and child healthSemantic proximity Read

Single-cell transcriptional profiling reveals cellular and molecular divergence in human maternal–fetal interfaceSemantic proximity Read

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA SequencingSemantic proximity Read

Single‐cell and spatial transcriptomics: Discovery of human placental development and diseaseSemantic proximity Read

Single-cell RNA-seq reveals developmental deficiencies in both the placentation and the decidualization in women with late-onset preeclampsiaSemantic proximity Read

Placenta at single-cell resolution in early and late preeclampsia: insights and clinical implicationsSemantic proximity Read

Single-cell mapping of maternal–fetal cross-talk in preeclampsiaSemantic proximity Read

Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamicsSemantic proximity Read

Dissecting human trophoblast cell transcriptional heterogeneity in preeclampsia using single‐cell RNA sequencingSemantic proximity Read

Two distinct molecular faces of preeclampsia revealed by single-cell transcriptomicsSemantic proximity Read

Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placentaSemantic proximity Read