Article

B cell directed CAR-T cell therapy results in activation of CD8+ cytotoxic CAR-negative bystander T cells in both non-human primates and patients

2023-09-29

Abstract excerpt

There is growing appreciation for the emergence of CAR neg bystander T cells after CAR-T cell infusion. However, their phenotypic and transcriptomic hallmarks and mechanisms of activation remain uncertain. We performed single-cell RNA-Seq (scRNA-Seq) on non-human primate (NHP) and patient-derived T cells to interrogate CAR neg T cells following B cell targeted CAR-T cell therapy. In a NHP model, we observed a di...

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Literature Corpus work: dc9da310-bb42-5ae8-b4e2-69a9713e28d5
DOI: 10.1101/2023.09.28.559936

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B cell directed CAR-T cell therapy results in activation of CD8+ cytotoxic CAR-negative bystander T cells in both non-human primates and patientsDOI 10.1101/2023.09.28.559936Read

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