Article

Rapid Telomere Shortening in Children

1999-05-01

Abstract excerpt

Abstract Telomere shortening may reflect the total number of divisions experienced by a somatic cell and is associated with replicative senescence. We found that the average rate of telomere shortening in peripheral blood mononuclear cells (PBMCs) obtained longitudinally from nine different infants during the first 3 years of life (270 bp per year) is more than fourfold higher than in adults and does not correlate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc67909c-cee0-52c5-b068-9efac52b9cd4
DOI: 10.1182/blood.v93.9.2824

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapid Telomere Shortening in ChildrenDOI 10.1182/blood.v93.9.2824Read

Rapid Telomere Shortening in ChildrenSemantic proximity Read

The Magnitude of Telomere Shortening per Cell Division In Vivo: Implications for Lifelong Hematopoiesis in HumansSemantic proximity Read

The rate of telomere sequence loss in human leukocytes varies with ageSemantic proximity Read

Leukocyte Telomere Length in HIV-Infected and HIV-Exposed Uninfected Children: Shorter Telomeres with Uncontrolled HIV ViremiaSemantic proximity Read

Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanismsSemantic proximity Read

Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and agingSemantic proximity Read

Biological Aging and Immune Senescence in Children with Perinatally Acquired HIVSemantic proximity Read

Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with AgeSemantic proximity Read

Accelerated replicative senescence of the peripheral immune system induced by HIV infectionSemantic proximity Read

Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell PoolSemantic proximity Read

Telomere length tracking in children and their parents: implications for adult onset diseasesSemantic proximity Read

Telomere lengthening and telomerase activation during human B cell differentiationSemantic proximity Read