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Article

The rate of telomere sequence loss in human leukocytes varies with age

12 May 1998

Abstract excerpt

A gradual loss of telomeric repeat sequences with aging previously has been noted in normal adult tissues, and this process has been implicated in cell senescence. No data exist that address the rate of telomere shortening in normal human cells within families or early in life. To address these questions, we measured telomere lengths in peripheral blood leukocytes (PBLs) from 75 members of 12 families and in a...

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PMID: 9576930
DOI: 10.1073/pnas.95.10.5607

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