Article

DeepMotifSyn: a deep learning approach to synthesize heterodimeric DNA motifs

2021-02-23

Abstract excerpt

<h4>Motivation</h4> The cooperativity of transcription factors (TFs) is a widespread phenomenon in the gene regulation system. However, the interaction patterns between TF binding motifs remain elusive. The recent high-throughput assays, CAP-SELEX, have identified over 600 composite DNA sites (i.e. heterodimeric motifs) bound by cooperative TF pairs. However, there are over 25,000 inferentially effective heterodi...

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Literature Corpus work: dc63c77b-a61d-5750-b9ff-eba30ba29435
DOI: 10.1101/2021.02.22.432257

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