Article

Aptamer charge-amplified field-effect transistor biosensors achieve picomolar detection limits for small-molecule biomarkers in complex biological matrices

2026-05-21

Abstract excerpt

Aptamers are attractive receptors for small-molecule biomarker detection in complex samples because of their high stability, affinity, and specificity, but aptamer-based sensors generally lack the sensitivity to detect low-abundance analytes. As a solution, we developed the charge-amplified FET (CAFET) aptamer biosensor, which is designed to amplify the net charge variation within the Debye length that occurs as a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc501b8f-736b-5d59-88c9-35bcbf332e06
DOI: 10.64898/2026.05.18.726065

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aptamer charge-amplified field-effect transistor biosensors achieve picomolar detection limits for small-molecule biomarkers in complex biological matricesDOI 10.64898/2026.05.18.726065Read

Label-free detection of single nucleotide polymorphisms utilizing the differential transfer function of field-effect transistors.Semantic proximity Read

Digital Immunoassay Protocol for Solid-State Nanopore SensingSemantic proximity Read

Establishing an RNA sensor with high sensitivity and dynamic range utilizing a signal amplifier platformSemantic proximity Read

FET Biosensors : Breast Cancer DetectionSemantic proximity Read

Material-Driven Enhancements in FET Biosensors for Cancer DiagnosisSemantic proximity Read

DNA Origami Signal Amplification in Lateral Flow ImmunoassaysSemantic proximity Read

Rapid Kinetic Fingerprinting of Single Nucleic Acid Molecules by a FRET-based Dynamic NanosensorSemantic proximity Read

A new era of semiconductor genetics using ion-sensitive field-effect transistors: the gene-sensitive integrated cell.Semantic proximity Read

HUNTER-Chip: Bioinspired Hierarchically Aptamer Structure-Based Circulating Fetal Cell Isolation for Non-Invasive Prenatal TestingSemantic proximity Read

DNA aptamer selection and construction of an aptasensor based on graphene FETs for Zika virus NS1 protein detectionSemantic proximity Read

Ultrasensitive in situ label-free DNA detection using a GaN nanowire-based extended-gate field-effect-transistor sensor.Semantic proximity Read

Re-engineering Electrochemical Aptamer-Based Biosensors to Tune Their Useful Dynamic Range via Distal-Site Mutation and Allosteric Inhibition.Semantic proximity Read