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HUNTER-Chip: Bioinspired Hierarchically Aptamer Structure-Based Circulating Fetal Cell Isolation for Non-Invasive Prenatal Testing

5 May 2021

Abstract excerpt

Isolation and genetic analysis of circulating fetal cells from billions of maternal cells in peripheral blood are the cornerstone of fetal cell-based non-invasive prenatal testing. Inspired by the hierarchically multivalent architecture for enhanced capture of nature, an aptamer-based Hierarchically mUltivalent aNTibody mimic intERface (HUNTER) was designed with a tremendous avidity effect for highly efficient...

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Share to Advanced biosensing and bioanalysis techniques
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Share to Prenatal Screening and Diagnostics

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PMID: 33949845
DOI: 10.1021/acs.analchem.1c00330

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