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α-synuclein overexpression and the microbiome shape the gut and brain metabolome in mice

30 Oct 2024

Abstract excerpt

Pathological forms of α-synuclein contribute to synucleinopathies, including Parkinson's disease (PD). Most cases of PD arise from gene-environment interactions. Microbiome composition is altered in PD, and gut bacteria are causal to symptoms in animal models. We quantitatively profiled nearly 630 metabolites in the gut, plasma, and brain of α-synuclein-overexpressing (ASO) mice, compared to wild-type (WT)...

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PMID: 39477976
DOI: 10.1038/s41531-024-00816-w

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