Article

Aggregation-prone alpha-synuclein proteoforms and dysregulated molecular signatures in the vermiform appendix of synucleinopathy patients

2025-10-07

Abstract excerpt

Synucleinopathies, including Parkinson’s disease, are neurodegenerative diseases characterized by intracellular inclusions containing the amyloidogenic protein alpha-synuclein. While classically considered to be brain disorders, increasing evidence suggests involvement of the gut, with alpha-synuclein aggregates potentially propagating to the brain via the vagus nerve. Evidence also suggests that the vermiform app...

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Literature Corpus work: 86b78228-93a7-5a9b-b6f0-480bb23eb9fe
DOI: 10.1101/2025.10.07.680938

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