Article

α-Synuclein Overexpression and the Microbiome Shape the Gut and Brain Metabolome in Mice

2024-06-10

Abstract excerpt

Pathological forms of the protein α-synuclein contribute to a family of disorders termed synucleinopathies, which includes Parkinson’s disease (PD). Most cases of PD are believed to arise from gene-environment interactions. Microbiome composition is altered in PD, and gut bacteria are causal to symptoms and pathology in animal models. To explore how the microbiome may impact PD-associated genetic risks, we quantit...

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Literature Corpus work: 27d2f07e-a755-5238-8f7f-2d0c537f2c4b
DOI: 10.1101/2024.06.07.597975

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