Article

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies

2022-05-01

Abstract excerpt

N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common subtype of autoimmune encephalitis characterized by a complex neuropsychiatric syndrome ranging from memory impairment and psychosis to coma. Patients develop an intrathecal immune response against NMDARs with antibodies that presumably bind to the amino-terminal domain (ATD) of the GluN1 subunit. The therapeutic response to immunotherapy is oft...

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Literature Corpus work: dc34a444-7e51-5e44-be9a-b9df4616ded8
DOI: 10.1101/2022.04.29.490085

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