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Article

Monoclonal antibodies from a patient with anti‐ NMDA receptor encephalitis

5 Jul 2018

Abstract excerpt

OBJECTIVE: -methyl-D-aspartate receptor (NMDAR). We sought to clone and characterize monoclonal antibodies (mAbs) from an ANRE patient. METHODS: We used a hybridoma method to clone two IgG mAbs from a female patient with ANRE without teratoma, and characterized their binding activities on NMDAR-transfected cell lines, cultured primary rat neurons, and mouse hippocampus. We also assessed their effects on voluntary...

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PMID: 30128318
DOI: 10.1002/acn3.592

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