Article

Redundancy in the central tachykinin systems safeguards puberty onset and fertility

2018-10-15

Abstract excerpt

<h4>ABSTRACT</h4> The tachykinin neurokinin B (NKB, Tac2 ) is critical for GnRH release. NKB signaling deficiency leads to infertility in humans. However, some patients reverse this hypogonadism resembling the fertile phenotype of Tac2 KO and Tacr3 KO (encoding NKB receptor, NK3R) mice despite the absence of NKB signaling. Here, we demonstrate that in the absence of NKB signaling, other tachykinins (substance...

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Literature Corpus work: dc253594-cacf-5be7-a430-f76dce4f49a5
DOI: 10.1101/443333

Open publication

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