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Article

Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men.

Endocrinology - 1 Mar 2012

Yang Jasmine J, Caligioni Claudia S, Chan Yee-Ming, Seminara Stephanie B

Abstract excerpt

Patients bearing mutations in TAC3 and TACR3 (which encode neurokinin B and its receptor, respectively) have sexual infantilism and infertility due to GnRH deficiency. In contrast, Tacr3(-/-) mice have previously been reported to be fertile. Because of this apparent phenotypic discordance between mice and men bearing disabling mutations in Tacr3/TACR3, Tacr3 null mice were phenotyped with close attention to...

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Source

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Identifiers

PMID: 22253416
DOI: 10.1210/en.2011-1949
PMCID: PMC3281542

Genes

TACR3
TAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men.PMID 22253416Read ↗

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