Article
Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice.
Endocrinology - 1 Apr 2015
True Cadence, Nasrin Alam Sayeda, Cox Kimberly, Chan Yee-Ming, Seminara Stephanie B
Abstract excerpt
Humans carrying mutations in neurokinin B (NKB) or the NKB receptor fail to undergo puberty due to decreased secretion of GnRH. Despite this pubertal delay, many of these patients go on to achieve activation of their hypothalamic-pituitary-gonadal axis in adulthood, a phenomenon termed reversal, indicating that NKB signaling may play a more critical role for the timing of pubertal development than adult...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.