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Article

Neurokinin 3 receptor antagonism decreases gonadotropin and testosterone secretion in healthy men.

Clinical endocrinology - 1 Dec 2017

Skorupskaite Karolina, George Jyothis T, Veldhuis Johannes D, Millar Robert P, Anderson Richard A

Abstract excerpt

OBJECTIVE: Patients with mutations of neurokinin B (NKB) and its receptor show hypogonadotrophic hypogonadism, but there is little evidence for the importance of this pathway in reproductive function in normal men, or its functional hierarchy with kisspeptin. DESIGN: An open label study wherein men (n = 6) were administered the NK3R antagonist MLE4901 40 mg orally twice a day for 7 days. Kisspeptin-10 (0.3 μg/kg...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28802064
DOI: 10.1111/cen.13445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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