Article
Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: physiological, pathophysiological and therapeutic implications.
Neuroendocrinology - 1 Jan 2013
Young Jacques, George Jyothis T, Tello Javier A, Francou Bruno, Bouligand Jerome, Guiochon-Mantel Anne, Brailly-Tabard Sylvie, Anderson Richard A, Millar Robert P
Abstract excerpt
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction. Kisspeptin and neurokinin B (NKB), neuropeptides secreted by the same neuronal population in the ventral hypothalamus, have emerged recently as critical central regulators of GnRH and thus gonadotropin secretion. Patients with mutations resulting in...
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