Article

Endothelin-1 as an Activator of Pro-inflammatory Microglia Cells

2024-09-11

Abstract excerpt

Microglial cells are highly specialized central nervous system (CNS) cells that can promote the inflammation and neurodegeneration seen in Multiple Sclerosis (MS). MS is a neurodegenerative autoimmune disease characterized by inflammation, demyelination, and axonal degeneration. In MS patients, demyelination is associated with activated microglia. Endothelin-1 (ET-1) is a potent vasoconstrictor that induces severe...

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Literature Corpus work: dbc581b8-a802-5601-ae6e-dafa26261fab
DOI: 10.20944/preprints202409.0918.v1

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