Article

Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma

2023-06-28

Abstract excerpt

<h4>ABSTRACT</h4> The DNAJ-PKAc fusion kinase is a defining feature of the adolescent liver cancer fibrolamellar carcinoma (FLC). A single lesion on chromosome 19 generates this mutant kinase by creating a fused gene encoding the chaperonin binding domain of Hsp40 (DNAJ) in frame with the catalytic core of protein kinase A (PKAc). FLC tumors are notoriously resistant to standard chemotherapies. Aberrant kinase ac...

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Literature Corpus work: db9d40a7-9101-5f92-ae37-ce46fea8e8d9
DOI: 10.1101/2023.06.28.546958

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