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DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic PathwaysDNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways

2024-11-19

Abstract excerpt

<h4>Background and Aims: </h4> Hepatoblastoma (HBL) and Fibrolamellar hepatocellular carcinoma (FLC) are the most common liver malignancies in children and young adults. FLC oncogenesis is associated with generation of the fusion kinase, DNAJB1-PKAc (J-PKAc). The J-PKAc has been found in 90% of FLC patients’ tumors, but not in other liver cancers. Since previous studies of J-PKAc were performed with adolescent pat...

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Literature Corpus work: 5b32d8f9-e51f-5b0d-9fa0-8bcad66dc7f0
DOI: 10.20944/preprints202411.1235.v1

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