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Article

Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.

Pediatric research - 1 Jul 2016

Riggle Kevin M, Riehle Kimberly J, Kenerson Heidi L, Turnham Rigney, Homma Miwako K, Kazami Machiko, Samelson Bret, Bauer Renay, McKnight G Stanley, Scott John D, Yeung Raymond S

Abstract excerpt

BACKGROUND: Fibrolamellar hepatocellular carcinoma (FL-HCC) affects children without underlying liver disease. A consistent mutation in FL-HCCs leads to fusion of the genes encoding a heat shock protein (DNAJB1) and the catalytic subunit of protein kinase A (PRKACA). We sought to characterize the resultant chimeric protein and its effects in FL-HCC. METHODS: The expression pattern and subcellular localization of...

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Share to 8-Bromo Cyclic Adenosine Monophosphate
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27027723
DOI: 10.1038/pr.2016.36
PMCID: PMC5105330

Genes

PRKACA
DNAJB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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