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Regulation of hemolysin in uropathogenicEscherichia colifine-tunes killing of human macrophages

23 Apr 2018

Abstract excerpt

Uropathogenic E. coli (UPEC) causes the majority of urinary tract infections (UTIs), which are a major global public health concern. UPEC uses numerous mechanisms to subvert the innate immune system, including targeting macrophage functions. We recently showed that some UPEC strains rapidly kill human macrophages via an NLRP3-independent pathway, and also trigger NLRP3-dependent IL-1β processing. In this study,...

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PMID: 29683762
DOI: 10.1080/21505594.2018.1465786

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