Article

A microRNA atlas of the human prefrontal cortex across the adult lifespan

2026-05-28

Abstract excerpt

Aging of the human brain is characterized by widespread changes in gene expression regulated in part by microRNAs (miRNAs). We present a lifespan miRNA atlas of the human dorsolateral prefrontal cortex generated from small RNA sequencing of 113 postmortem samples spanning 18 to 100 years of age. Differential expression analysis revealed progressive age-associated remodeling of miRNA expression, with the strongest...

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Literature Corpus work: db8ced6e-a1f7-5be6-b7ba-a02dd098e79c
DOI: 10.64898/2026.05.27.728239

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