Article
Local CpG density affects the trajectory of age-associated epigenetic changes
2021-07-09
Abstract excerpt
DNA methylation is an epigenetic mark associated with gene repression and genome stability. Its pattern in the genome is disrupted with age and these changes can be used to statistically predict age with epigenetic clocks. Rates of aging inferred from these clocks correlate with human health. However, the molecular mechanisms underpinning age-associated DNA methylation changes are unknown. Local DNA sequence plays...
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Identifiers and source
- Literature Corpus work
- db7f0c48-e632-529d-b512-4af8ed80a522
- DOI
- 10.1101/2021.07.08.451539