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Article

Genetic and environmental exposures constrain epigenetic drift over the human life course.

Genome research - 1 Nov 2014

Shah Sonia, McRae Allan F, Marioni Riccardo E, Harris Sarah E, Gibson Jude, Henders Anjali K, Redmond Paul, Cox Simon R, Pattie Alison, Corley Janie, Murphy Lee, Martin Nicholas G, Montgomery Grant W, Starr John M, Wray Naomi R, Deary Ian J, Visscher Peter M

Abstract excerpt

Epigenetic mechanisms such as DNA methylation (DNAm) are essential for regulation of gene expression. DNAm is dynamic, influenced by both environmental and genetic factors. Epigenetic drift is the divergence of the epigenome as a function of age due to stochastic changes in methylation. Here we show that epigenetic drift may be constrained at many CpGs across the human genome by DNA sequence variation and by...

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Identifiers

PMID: 25249537
DOI: 10.1101/gr.176933.114
PMCID: PMC4216914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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