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Article

Decoupling expression and editing preferences of ADAR1 p150 and p110 isoforms.

Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2021

Sun Tony, Yu Yingpu, Wu Xianfang, Acevedo Ashley, Luo Ji-Dung, Wang Jiayi, Schneider William M, Hurwitz Brian, Rosenberg Brad R, Chung Hachung, Rice Charles M

Abstract excerpt

Human adenosine deaminase acting on RNA 1 (ADAR1) catalyzes adenosine-to-inosine deamination reactions on double-stranded RNA molecules to regulate cellular responses to endogenous and exogenous RNA. Defective ADAR1 editing leads to disorders such as Aicardi-Goutières syndrome, an autoinflammatory disease that manifests in the brain and skin, and dyschromatosis symmetrica hereditaria, a skin pigmentation...

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Source

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Identifiers

PMID: 33723056
DOI: 10.1073/pnas.2021757118
PMCID: PMC8000508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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